The Guide and Policies for the Use of Artificial Intelligence in Education and Scientific Research at King Abdulaziz University constitute an advisory and regulatory framework aimed at guiding the responsible and effective use of artificial intelligence technologies in education, scientific research, and administrative operations. The guide addresses the University’s institutional perspective, national and international references, principles of ethical, educational, and research use, applied models, and an adoption roadmap, thereby enhancing the quality of education and research, supporting innovation, and improving the efficiency of academic and administrative practices under responsible and sustainable controls.