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Document Type |
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Thesis |
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Document Title |
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THE ASSOCIATION OF IRISIN, RETINOL BINDING PROTEIN 4 ( RBP4) AND LEPTIN AS MARKERS OF INFLAMATION WITH CARDIOVASCULAR COMPLICATIONS IN TYPR 2 DIABETETES MELLITUS. ارتباط الايرسين و البروتين الرابط للريتنول 4 و هرمون اللبتين كدلالات للالتهاب مع مضاعفات القلب و الاوعية الدموية في مرضي البول السكري من النوع الثاني |
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Subject |
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Faculty of medicine |
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Document Language |
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Arabic |
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Abstract |
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Background and aim: Worldwide cardiovascular disease (CVD) is a major epidemic inflammatory disorder boosted by type 2 diabetes mellitus (T2DM). The risk of CVD increases 2-4 folds in T2DM. Markers of inflammation have been implicated in predicting vascular complications of T2DM. A recent anti-inflammatory myokine irisin has been linked to diabetes, insulin resistance and diabetic complications. Retinol binding protein-4 (RBP4) and leptin are proinflammatory adipokines that have been associated with the risk of T2DM and its complications. Therefore, we aimed to study the association of irisin, retinol binding protein 4 (RBP4) and leptin as markers of inflammation with cardiovascular complications in T2DM patients.
Subjects and methods: A case control study design was employed. A total of 90 participants, categorized into: 30 healthy control subjects, 30 T2DM patients without CVD, and 30 T2DM patients with CVD were included. The levels of irisin, RBP4 and leptin were measured and compared between the three groups.
Results: Serum irisin levels were significantly higher in the two diabetic groups compared to the control group. Interestingly serum irisin levels were higher in T2DM patients with CVD group compared to T2DM without CVD group. RBP4 serum levels were significantly higher in the two diabetic groups compared to the control group. However, it did not show significant difference between T2DM patients with and without CVD groups. Lastly, serum leptin levels were not significantly different between T2DM patients without CVD group and control subjects. Whereas its levels showed significantly higher values in T2DM patients with CVD group compared to control group. However, there were no significant differences in serum leptin levels between the groups of T2DM patients with and without CVD.
Conclusion: The myokine irisin shows promise as a marker to detect cardiovascular complications of T2DM. Our results may suggest the beneficial and anti-inflammatory properties of irisin in T2DM and its cardiovascular complications. Therefore, more larger studies are needed to find the possible diagnostic, prognostic and therapeutic role of irisin in T2DM. |
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Supervisor |
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Prof. Enayat M. Hashem |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Added Date |
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Tuesday, September 25, 2018 |
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Researchers
| إهداء يوسف علي | Ali, Ehdaa Yousef | Researcher | Master | |
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