Document Details

Document Type : Thesis 
Document Title :
EFFECT OF RED SWEET PEPPER ON OBESE MALE RATS FED ON A HIGH-FAT DIET
تأثير الفلفل الأحمر الحلو علي السمنة في ذكور الجرذان والتي تتغذي على حمية عالية في الدهون
 
Subject : College of Home Economics 
Document Language : Arabic 
Abstract : Objective: The present study was carried out to evaluate the effects of red sweet pepper ethanol extract (RSPE) oral administration at three dosage levels (200, 400, and 600 mg/kg b. wt.) in obese male rats for 4 weeks on body weight gain percent (BWG%), feed efficiency ratio (FER), and lipid profile. Liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were determined. Histopathological examination of liver, heart and fat were also carried out. Methods: Twenty five male Wistar rats were distributed into five equal groups as follows: Group (1) negative control (normal diet), the rats of the other four groups were fed a high fat diet for 8 weeks. After the 8- week period, the average weekly body weight gain in the rats fed the high fat diet was twice as much as that in the control group. Serum levels of triglyceride (TG) and total cholesterol (TC) were also elevated. Then the four groups were divided into: Group (2) positive control (rats fed a high fat diet ) and the three other groups were fed a high fat diet and orally given sweet red pepper extract (RSPE) at doses of 200, 400and 600 ml/kg b. wt. a, respectively for 4 weeks. Results: The results showed that oral administration of RSPE to obese rats for 4 weeks significantly decreased serum levels of TC, TG, low density lipoprotein (LDL-c) and very low density lipoprotein (VLDL-c) accompanied by an increase in the level of high density lipoprotein (HDL-c) when compared to the positive control group. There was a significant decrease in liver enzymes (ALT & AST) as compared to the control positive group. Histopathological examination of liver, heart and fat of sweet pepper extract-treated groups showed amelioration of histological changes caused by high fat diet in the positive control group. Conclusion: Results indicated that RSPE decreases body weight gain percent, suppresses fat accumulation and decreases levels of TC, TG, and LDL and increases HDL in obese rats. There was a decrease in liver enzymes as compared to positive control group. The high dose (600mg) was the most effective dose. This study recommends that consuming pepper extract may be beneficial for people who suffer from obesity and hyperlipidemia. 
Supervisor : Dr. Maha Ahmed Al-ahdab 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Added Date : Monday, January 8, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أريج عبدالرحمن نصيفNaseif, Areej AbdulrahmanResearcherMaster 

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