Document Details

Document Type : Article In Journal 
Document Title :
Evaluation of matrix metalloproteinases, cytokines and their potential role in the development of ovarian cancer
Evaluation of matrix metalloproteinases, cytokines and their potential role in the development of ovarian cancer
 
Document Language : English 
Abstract : Background Ovarian cancer is the 5th most common cause of deaths in the women among gynecological tumors. There are many growing evidences that stress and other behavioral factors may affect cancer progression and patient survival. The purpose of this study is to determine the key role of matrix metalloproteinases (MMPs), and cytokines in the aggregation and progression of ovarian cancer. Methodology Stress variables (MDA, AGEs, AOPPs, NO), profile of antioxidants (SOD, Catalase, Vitamin E & A, GSH, GRx, GPx) and inflammatory biomarkers (MMP-9, MMP-2, MMP-11, IL-1α and TNF-α) were biochemically assessed from venous blood of fifty ovarian cancer patients and twenty healthy control subjects. The results of all parameters were analyzed statistically by independent sample t-test. Results The results of the study demonstrated that the levels of stress variables like MDA (3.38±1.12nmol/ml), AGEs (2.72±0.22 ng/ml), AOPPs (128.48±27.23 ng/ml) and NO (58.71±8.67 ng/ml) were increased in the patients of ovarian cancer as compared to control individuals whereas the profile of antioxidants like SOD, Catalase, Vitamin E, Vitamin A, GSH and GRx were decreased in ovarian cancer patients (0.11±0.08 μg/ml, 2.41±1.01μmol/mol of protein, 0.22±0.04 μg/ml, 45.84±9.07μg/ml, 4.88±1.18μg/ml, 5.33±1.26 μmol/ml respectively). But the level of GPx antioxidant was increased in ovarian cancer patients (6.58±0.21μmol/ml). Moreover the levels of MMP-9 (64.87±5.35 ng/ml), MMP-2 (75.87±18.82 ng/ml) and MMP-11 (63.58±8.48 ng/ml) were elevated in the patients. Similarly, the levels of various cytokines TNF-α and IL-1α were also increased in the patients of ovarian cancer (32.17±3.52 pg/ml and 7.04±0.85 pg/ml respectively). Conclusion MMPs are commonly expressed in ovarian cancer which are potential extrapolative biomarkers and have a major role in metastasis. Due to oxidative stress, different cytokines are released by tumor associated macrophages (TAMs) that result in the cancer progression. Consequently, tissue inhibitors of matrix metalloproteinases (TIMPs) are the valuable therapeutic approaches to complement conservative anticancer strategies. 
ISSN : 1932-6203 
Journal Name : PloS one 
Volume : 11 
Issue Number : 11 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Tuesday, July 18, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mahmood RasoolRasool, Mahmood ResearcherDoctorate 
Arif MalikMalik, Arif ResearcherDoctorate 
Muhammad Abdul Basit AshrafAshraf, Muhammad Abdul BasitResearcherDoctorate 
Gulshan ParveenParveen, Gulshan ResearcherDoctorate 
Shazia IqbalIqbal, Shazia ResearcherDoctorate 
Irfan AliAli, Irfan ResearcherDoctorate 
Mahmood Husain QaziQazi, Mahmood HusainResearcherDoctorate 
Muhammad AsifAsif, Muhammad ResearcherDoctorate 
Kashif KamranKamran, Kashif ResearcherDoctorate 
Asim IqbalIqbal, Asim ResearcherDoctorate 
Saima IramIram, Saima ResearcherDoctorate 
Sami Ullah KhanKhan, Sami UllahResearcherDoctorate 
Mohammad Zahid MustafaMustafa, Mohammad ZahidResearcherDoctorate 
Ahmad ZaheerZaheer, Ahmad ResearcherDoctorate 
Rozeena ShaikhShaikh, Rozeena ResearcherDoctorate 
Hani ChoudhryChoudhry, Hani ResearcherDoctorate 
Mohammad Sarwar JamalJamal, Mohammad SarwarResearcherDoctorate 

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