Center of Excellence In Genomic Medicine Research | Researches | SNP variation with latitude: Analysis of the SNPforID 52-plex markers in north, mid-region and south Chilean populations

Center of Excellence In Genomic Medicine Research

Document Details

Document Type	:	Article In Journal
Document Title	:	SNP variation with latitude: Analysis of the SNPforID 52-plex markers in north, mid-region and south Chilean populations SNP variation with latitude: Analysis of the SNPforID 52-plex markers in north, mid-region and south Chilean populations
Document Language	:	English
Abstract	:	Abstract Chile is a disproportionately long and narrow country defined by the southern Andes and Pacific coastline where a level of genetic sub-structure resulting from distances of several thousand kilometers might be expected across the most distantly separated regions. Although STR databases created for the Chilean Legal Medical Service indicate an absence of sub-structure, such a characteristic requires further exploration when introducing additional forensic markers. Notably, Single Nucleotide Polymorphisms (SNPs) have a much lower mutation rate than STRs and can show more stable distributions of genetic variation if population movement is restricted. In this study we evaluated 451 Chilean urban samples from the North, North-Central, Central, South-Central and South regions of Chile for the 52 SNPs of the SNPforID forensic identification panel to explore the underlying genetic structure of Chilean populations. Results reveal similar genetic distances between groups suggesting a single SNP database for the whole of Chile is appropriate. To further understand the genetic composition of Chilean populations that comprise the bulk of individuals with both European and Native American ancestries, ancestral membership proportions were evaluated and pairwise comparisons to other American populations were made.
ISSN	:	1872-4973
Journal Name	:	Forensic Science International: Genetics
Volume	:	10
Issue Number	:	1
Publishing Year	:	1435 AH 2014 AD
Article Type	:	Article
Added Date	:	Tuesday, March 8, 2016

Researchers

Researcher Name (Arabic)	Researcher Name (English)	Researcher Type	Dr Grade	Email
F Moreno	Moreno, F	Investigator
A Freire-Aradas	Freire-Aradas, A	Researcher
C Phillips	Phillips, C	Researcher
M Fondevila	Fondevila, M	Researcher
A Carracedo	Carracedo, A	Researcher
MV Lareu	Lareu, MV	Researcher

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