Document Details

Document Type : Article In Journal 
Document Title :
Prevalence of mutation and phenotypic expression associated with sulfadoxine-pyrimethamine resistance m Plasmodium falciparum and Plasmodium vivax
مدى انتشار التحول الجيني والعرض الشكلي المتعلق بمقاومة عقار سالفادوكسين بايرميثامين في الملاريا الخبيثة والملاريا الحميدة
 
Subject : Malaria 
Document Language : English 
Abstract : Therapeutic efficacy of sulfadoxine-pyrimethamine (SP), which is commonly used to treat falciparum malaria, was assessed in isolates or Plasmodium falciparum (Welch, 1897) and Plasmodium vivax (Grassi et Feietti, 1890) of Aligarh, Uttar Pradesh, North India and Taif Saudi Arabia during 2011-2012. Both the species showed mutations in dihydrofolate reductase (DHFR) enzyme as they have common biochemical drug targets. Mutation rate for pfdhfr was higher compared to pvdhfr because the drug was mainly given to treat falciparum malaria. Since both the species coexist, P vivax was also exposed to SP due to faulty species diagnosis or medication without specific diagnosis. Low level of mutations against SP in P.falciparum of Saudi isolates indicates that the SP combination is still effective for the treatment of falciparum malaria. Since SP is used as first-line of treatment because of high level of resistance against chloroquine (CQ), it may result in spread of higher level of mutations resulting in drug resistance and treatment failure in near future. Therefore, to avoid further higher mutations in the parasite, use of better treatment regimens such artesurate combination therapy must be introduced against SP combination 
ISSN : 0015-5683 
Journal Name : FOLIA PARASITOLOGICA 
Volume : 60 
Issue Number : 4 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Thursday, May 22, 2014 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هيثم أحمد زكائيZakai, Haytham AhmedInvestigatorDoctoratehzakai@kau.edu.sa

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