Document Details

Document Type : Article In Journal 
Document Title :
protective effect of ascorbic acid on cisplatin genotoxicity in male mice bone marrow cells
تأثير وقائي من حمض الاسكوربيك على السمية الجينية في سيسبلاتين ذكر الفئران خلايا نخاع العظام
 
Subject : protective effect of ascorbic acid on cisplatin genotoxicity in male mice bone marrow cells 
Document Language : English 
Abstract : Cisplatin (cis-diamminedichloroplatinum II) is an effective antitumor agent with a wide spectrum of activity against varies solid tumors, but it has serious side effects on nontumour cells. Cisplatin produces intra- and interstrand DNA cross-linking effects and chromosomal aberrations in mammalian cells. Vitamin C (ascorbic acid) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA, from oxidative damage induced by different agents. Pretreatment administration of ascorbic acid on cisplatin induced chromosome aberrations has been determined in bone marrow cells of Swiss albino mice. Results showed that cisplatin (7.5 & 10mg/kg bw)IP injection to male mice induced significant increase in the frequencies of chromosomal aberrations. The results of pre-treatment with ascorbic acid (66mg/kg bw) showed a significant decrease in the number of chromosomal aberrations induced with cisplatin tested doses. Ascorbic acid did not exhibit any clastogenic effect in male mice bone marrow cells. We concluded that ascorbic acid has a protective role against the genotoxicity induced by antitumor drug cisplatin. 
ISSN : 2411-0013 
Journal Name : Egyptian Medical Journal 
Volume : 18 
Issue Number : 1 
Publishing Year : 1425 AH
2005 AD 
Article Type : Article 
Added Date : Wednesday, February 20, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ندى حسن التواتيTouati, Nada HassanInvestigatorDoctoratenaltwaty@yahoo.com

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