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Document Type |
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Thesis |
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Document Title |
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Impact of Leptin Receptor Gene GLN223ARG Polymorphism on Obesity in Jeddah City تأثير التعدد الشكلي لمستقبل جين السمنة GLN223ARG على السمنة في مدينة جدة |
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Subject |
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biological sciences department |
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Document Language |
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Arabic |
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Abstract |
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Obesity is a major global epidemic problem. Obesity is a complex disorder resulting from a net imbalance between genetic, energy intake and expenditure. Obesity results from the combined effects of genes, environment, lifestyle and the interactions of these factors. The leptin receptor gene plays a critical role in the regulation of body weight. Genetic variations of leptin receptor gene may play a role in the pathophysiology of human obesity. In this study, the association between the LepR gene polymorphism and obesity in Jeddah city population was evaluated by determine the distribution of alleles frequency of the leptin receptor GLN223ARG polymorphism in 180 volunteers (94 male & 86 female) from Jeddah population. Each gender was divided into two groups: from 6-17 years old (Children and Teenager), and from 18-27 years old (Adults). As well as each group were divided into two sub-groups according to BMI (obese and non obese "control"). When comparison the obese and non obese groups, results demonstrated that no significant difference between genotype distribution and body mass index (BMI), weight, hip, waist and waist-hip ratio (WHR). In contrast, there was a significant increase in GG genotype (OR= 19.11, 95%CI: 0.95-384.95, P= 0.01) compared to AA genotype, and GG genotype (OR= 25.24, 95%CI: 1.25-509.46, P= 0.006) compared to AG genotype in males children and teenagers, which suggests that genetic polymorphisms (GLN223ARG) of leptin receptor gene may play a role in prevalence of obesity children and teenagers males this group obesity. |
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Supervisor |
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Dr. Sabah Abdulaziz Linjawi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1433 AH
2012 AD |
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Added Date |
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Monday, September 24, 2012 |
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Researchers
| نــــور أحمــد حســــين | Hussein, Noor Ahmed | Researcher | Master | |
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