Document Details

Document Type : Article In Journal 
Document Title :
Cytotoxicity of 45S5 bioglass paste used for dentine hypersensitivity treatment
Cytotoxicity of 45S5 bioglass paste used for dentine hypersensitivity treatment
 
Document Language : English 
Abstract : 45S5 bioglass mixed with 50% phosphoric acid has been suggested to treat dentine hypersensitivity and incipient enamel caries. This study is going to evaluate the biocompatibility of using the aforementioned technique with the rat pulpal cells. Methods: The relative cytotoxicity of 45S5 bioglass on rat dental pulp cells was compared to the cytotoxicity of a temporary filling material (Caviton; GC, Japan), Type 1 glass ionomer cement (Fuji I; GC, Tokyo, Japan) and commercial desensitising agent (SuperSeal; Phoenix Dental, Fenton, MI, USA) using a transwell insert model. Cell viability was measured by means of a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The number of viable cell counts were compared using one way ANOVA ( p < 0.05). The morphological alterations of the pulp cells were observed directly by phase contrast microscope. Results: The results of this study indicated that cell viability recorded by the 45S5 bioglass paste group did not differ significantly from those of the Caviton, glass ionomer or superseal, moreover pulpal cells microscopic analysis revealed that 45S5 bioglass elicited minimal toxic effect. Conclusions: 45S5 bioglass paste can serve as a biocompatible material that can potentially be used safely on dentine. 
ISSN : 0300-5712 
Journal Name : j o u r n a l o f d e n t i s t r y 
Volume : 39 
Issue Number : 9 
Publishing Year : 1433 AH
2011 AD 
Article Type : Article 
Added Date : Saturday, February 18, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أحمد سمير بكريBakry, Ahmed SamirInvestigatorDoctorate 

Files

File NameTypeDescription
 32308.pdf pdf 

Back To Researches Page