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Document Type |
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Thesis |
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Document Title |
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Spectroscopic and Thermal Studies on the Kinetic of Charge-Transfer Interaction of Pantoprazole Drug with DDQ, CHLC and Iodine دراسات طيفية وحرارية على حركية تداخل انتقال الشحنة لدواء البنتوبرازول مع حمض الكلورانيلك واليود |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Pantoprazole and Omeprazole are aromatic heterocyclic compounds representing a very important class of compounds with possess a system of π and n electrons . Proton pump inhibitors (PPIs) which used as donor molecules, it included the different steps of the characterization of pantoprazole and omeprazole drugs under investigation by charge transfer complexation method. Since the formation of charge transfer compounds gives apportunity to improve the physical and chemical properties of different donors. Drugs as donors with different acceptors as 2,3-dhchloro-5,6-dicyano-1,4-benzoquinone (DDQ ), Iodine and 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (CHLC) were form complexes. The stoichiometry of reactions were determined from Gob's method of continuous variation. Spectrophotometric studies were used to find concentration effect ,solvent effect and kinetic studies also were studied under different temperetures to find the optimization conditions . It included also the estimation of the equilibrium constants and thermodynamic parameters . There are a solid complexes formed which characterize by IR and magnetic resonance method .
The kinetics of non isothermal decomposition in air were studied on solid state complexes using integral methods due to Coast Redfern method and Ozawa method, the results discussed under various solid state reaction models.The activation parameters and frequency factor estimated for each decomposition step, the results discussed by using differential scanning microscope.The morphology of complexes were determined using scanning electron microscope , it found that it had nanometric sizes. |
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Supervisor |
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PROF.El-sayed El-Badawy El-Mossalamy |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1432 AH
2011 AD |
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Co-Supervisor |
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Dr. Zaheer Khan |
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Added Date |
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Monday, July 18, 2011 |
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Researchers
| دعاء فوزي باعامر | Baaamer, Doaa Fowzi | Researcher | Master | |
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