Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Rituximab for refractory cases of childhood nephrotic syndrome ريتوكسيماب للحالات الغير مستجيبة للعلاج من المتلازمة الكلوية عند الأطفال |
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Subject |
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Hereditary Disorders |
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Document Language |
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English |
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Abstract |
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Rituximab has been used over the last decade as
a rescue therapy for refractory cases of nephrotic syndrome
(NS). Here we report the use of rituximab in four children
with idiopathic steroid-resistant nephrotic syndrome
(SRNS) with various histological backgrounds (two cases
with focal segmental glomerulosclerosis, one case with IgM
nephropathy, and one case with minimal change disease),
who failed to respond to other immunsuppressions. Their
median age (range) was 10 (8–11) years. NPHS2 genetic
mutation was negative in all of them. All patients received a
single dose of rituximab (375 mg/m2) and achieved
complete B cell depletion as CD19 was <1% for 3 months
following rituximab infusion. Only one patient achieved
non-sustained remission as he relapsed after 4 months
despite zero CD19 level. Patients received no further doses
of rituximab as B cell was depleted in the peripheral
circulation. We conclude that a single dose of rituximab
was not effective in inducing sustained remission in
children with idiopathic SRNS, despite complete B cell
depletion in the peripheral circulation. Further doses might
be indicated to deplete non-circulating B cells. |
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ISSN |
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1432-198X |
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Journal Name |
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Pediatric Nephrology |
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Volume |
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26 |
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Issue Number |
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5 |
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Publishing Year |
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1432 AH
2011 AD |
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Article Type |
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Article |
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Added Date |
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Monday, May 30, 2011 |
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Researchers
| جميلة قاري | Qari, Jameela | Investigator | Doctorate | |
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