Document Details

Document Type : Project 
Document Title :
Evaluation of the methods for tissue-based detection of the Her2/neu gene alteration in human breast cancer
تقييم الطرق التحليلية لتحديد وكشف التغيرات المصاحبة للطفرة الجينية Her2 لمرضى سرطان الثدي.
 
Subject : Evaluation of the methods for tissue-based detection of the Her2/neu gene alteration in human breast cancer 
Document Language : Arabic 
Abstract : HER-2 is a protoncogene located on chromosome 17. It encodes a transmembrane growth factor receptor with tyrosine kinase activity. Overexpression and/or amplification of HER-2 are detected in approximately 20% to 30% of invasive ductal carcinomas of the breast and have been associated with a poor prognosis.3 Amplification of the HER-2 oncogene and concomitant overexpression of protein are currently implicated in breast carcinoma as important biomarkers for predicting response to trastuzumab (Herceptin, Roche, Basel, Switzerland), which has signifgicant anti-tumour activity both as single agent and in combination with chemotherapy in these patients. For this reason, laboratory assessment of HER-2 status is becoming a key step in the optimal management t of patients with advanced breast cancer. Immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) have emerged as the two most widely used assays to evaluate HER-2 status in breast cancer. Both methods are recommended by national and international guidelines. Our aim will determine the aneusomy level and the HER-2 gene copy numbers, by fluorescence in situ hybridization (FISH) and to analyze their impact on the amplification rate in breast carcinomas considered HER-2 weekly positive cases by immunohistochemistry. 
Publishing Year : 1427 AH
2006 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1427 AH
2006 AD 
Added Date : Monday, June 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبد الحكيم محمد كيلانيKelany, Abdelhakim MohammedInvestigatorDoctorate 

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 27173.docx docx 

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