Document Details

Document Type : Article In Journal 
Document Title :
“Role of the neural cell adhesion molecule (N-CAM) in maintaining the integrity of the neuromuscular junction”
“Role of the neural cell adhesion molecule (N-CAM) in maintaining the integrity of the neuromuscular junction”
 
Document Language : English 
Abstract : The present study investigated the role of the neural cell adhesion molecule (N-CAM) in maintaining the integrity of the neuromuscular junction. Immunohistochemical localization of this molecule in muscle tissue of the rat was examined through double immunostaining of longitudinal cryostat sections for synaptophysin (a synaptic vesicle marker) and N-CAM. In addition, immuno-electron microscopy was performed to view the localization of N-CAM at the ultrastructural level. The results showed that N-CAM immunoreactivity at the neuromuscular junction was exclusively restricted to the contact area between the terminal Schwann cells and the nerve terminals. No reaction product could be seen between the pre- and postsynaptic membranes. Such localization of N-CAM implies that this molecule is not adequately positioned to play a role in maintaining the integrity of the neuromuscular junction, but rather mediates the axon-Schwann cell interactions. 
ISSN : 0969-711 
Journal Name : Al-Azhar Medical Journal 
Volume : 12 
Issue Number : 32 
Publishing Year : 2003 AH
2003 AD 
Article Type : Article 
Added Date : Sunday, March 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
شريف حسنHassan, Sherif ResearcherDoctorate 

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