Document Details

Document Type : Project 
Document Title :
Design and preparation of derivatives Alaraluxykil Secretary of Kmmathlat Seeratonin Kmsknat to test their impact with potential use as anti-migraine
: تصميم و تحضير مشتقات الاريلوكسىالكيل امين كمماثلات للسيراتونين لاختبار تأثيرها كمسكنات مع احتمال استخدامها كمضادات للصداع النصفي
 
Document Language : Arabic 
Abstract : We have found that the amendment in the structure of a compound Albroobranolol chemical - which is used in the medical field retardant receptor beta is also used as an adjunct in the treatment of migraine (migraine) as a result of its association with the weak Ptan future - h5-HT1B has resulted in vehicles Alaraluxykil secretary, which has a link to the largest relatively the same under the future but lack the selectivity and quality. So in this research was the preparation of compounds of the same group took into account the replacement of hydrogen at the site-α or-β in the group of alkyl side group, or methyl vinyl naphthalene in addition to the replacement of vinyl replacement sites in the 2.3 to 2.4 - 2.5 or 2 , 6 - Bhaloginat. Have been dating for new vehicles and precise quantitative analysis of nuclear magnetic resonance. And were also calculated for each characteristic fatty compound, as well as three-dimensional study of some vehicles and their conformity with the compound used model. Have been measured susceptibility number of vehicles in the link Ptan receptors 5-HT1b, 5-HT1d and found that some of his link to a high of more than a composite Albroobranolol Ptan future 5-HT1b a rate greater than the association Ptan future 5-HT1d and vice versa, which indicates the privacy of quality and selection of these vehicles. Also been tested for therapeutic effectiveness Kmsknat pain for a number of seven vehicles on the final laboratory rats and found to be effective, ranging from 66-100% compared to aspirin. 
Publishing Year : 1425 AH
2005 AD 
Sponsor Name : kau 
Sponsorship Year : 1425 AH
2005 AD 
Added Date : Wednesday, April 30, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالقادر مختار إسماعيلIsmaeil, abdulqader mokhtarInvestigatorDoctorate 

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