Document Details

Document Type : Thesis 
Document Title :
Effect of Thymoquinone and Vitamin E on Cisplatin Induced Nephropathy in Rats
تأثيرثيموكينون وفيتامين هـ على الاعتلال الكلوي المستحث بسيزبلاتين فى الجرذان
 
Subject : Faculty of Sciences > Biochemistry department 
Document Language : Arabic 
Abstract : Cisplatin is one of the most efficient anti-cancer drugs used against solid tumors. The effective dose of Cisplatin results in many side effects like hepatotoxicity and nephrotoxicity. Production of free radicals and oxidative stress are highly contributed to the induction and progression of cisplatin-nephrotoxicity. Thymoquinone and vitamin E are potent antioxidants and radical scavengers found naturally in many dietary products. Here we will investigate the efficacy of vitamin E and thymoquinone to attenuate the cisplatin-induced nephrotoxicity via their antioxidative/radical scavenging activities in rats. Different oxidant and antioxidant parameters are measured. In addition, the kidney function tests of the rats are assayed. Moreover, the activity of the antioxidant enzymes like SOD, catalase, GST, GSH. GSH-px are measured. Furthermore, the kidney tissue sections are stained with H&E stain for histopathological examination to see the effect of vitamin E and thymoquinone on the pathological status of the rat kidneys. 
Supervisor : Dr. Madeha Al-seeni 
Thesis Type : Master Thesis 
Publishing Year : 1435 AH
2014 AD 
Added Date : Thursday, August 21, 2014 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فاطمة عثمان الغامديAlghamdi, Fatima OthmanResearcherMaster 

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