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Document Type |
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Project |
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Document Title |
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Design and Synthesis of Naphthalimides as PPARα Agonists, Antihyperlipidemic, and Antiatherosclerotic Agents تصميم و تحضير مشتقات النافثليميدات كمحفزات لمستقبلات الاحماض الدهنيةPPARα ، |
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Subject |
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Design and Synthesis of Naphthalimides as PPARα Agonists, Antihyperlipidemic, and Antiatherosclerotic Agents |
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Document Language |
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Arabic |
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Abstract |
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Atherosclerosis is a condition underlying most cardiovascular diseases. The design of a drug has specific PPAR-activating properties (peroxisome proliferator-activated receptors) may be useful in the prevention of cardiovascular disease in a growing population suffering from hyperlipidemia or lifestyle-induced metabolic dysfunction. Defects in lipid metabolism are a major cause of cardiovascular disease, this is apparent in patients with familial hypercholesterolemia, or / and hypertriglyceridemia. Also, the elevated levels of the lipoproteins (LDL) and (VLDL) are usually associated with atheroma formation. Medicinal researches indicated that several cyclic and acyclic imide derivatives have demonstrated significant lowering of serum total cholesterol and total triglyceride levels in mice after 16 days of dosing at an optimum dose of 20mg/kg/day in comparison with clofibrate. The promising obtained results for the hypolipidemic activity of the 1,8-naphthalimido derivatives in experimental animals (research work of the project 048/1426H), strongly potentiate and recommend more researches in the area of the design and synthesis of novel naphthalimide derivatives to be evaluated as hypolipidemic agents. In the present project, the design and synthesis of a number of N-substituted naphthalimide derivatives including substituted aryl (I), substituted anilide (II), alkyl, methyl ketones, aminocarboxylic acid, and aminocarboxylic acid esters of varying chain length (III), is the objective of the project, aiming to obtain compounds of better antihyperlipidemic activity than the widely used and commercially available fibrates. |
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Publishing Year |
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1428 AH
2007 AD |
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Added Date |
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Tuesday, June 29, 2010 |
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Researchers
| ليلي محمود جاد | Gad, Laila Mahmoud | Investigator | Doctorate | |
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